×
Entrez Id: 2175
Gene Symbol: FANCA
FANCA
Leukemia, Myelocytic, Acute
0.530
GenomicAlterations
CGI
×
Entrez Id: 2176
Gene Symbol: FANCC
FANCC
Leukemia, Myelocytic, Acute
0.520
GenomicAlterations
CGI
×
Entrez Id: 2177
Gene Symbol: FANCD2
FANCD2
Leukemia, Myelocytic, Acute
0.510
GenomicAlterations
CGI
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.
14604974 2004
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968 2014
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways.
17047150 2007
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.
22504183 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CGI
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
11290608 2001
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.
22368270 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Recurring mutations found by sequencing an acute myeloid leukemia genome.
19657110 2009
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
[FMS-like tyrosine kinase 3 gene mutations in acute myeloid leukemia].
19840437 2009
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CGI
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic trioxide regimen.
17606455 2007
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
MicroRNAs in liver disease.
22504185 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3.
20733134 2010
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.
22504184 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
15256420 2004
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD.
23430109 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia.
23321257 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia.
23783394 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Mutational landscape of AML with normal cytogenetics: biological and clinical implications.
23261068 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy.
16857985 2006
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.
15374878 2005